John Libbey Eurotext

European Journal of Dermatology


Subungual melanoma complicated by hydroxyurea-induced melanonychia with non-melanoma Hutchinson's sign Volume 28, issue 4, July-August 2018


  • Figure 1
Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan

Hydroxyurea is an antineoplastic agent mainly used for the treatment of haematopoietic disorders including chronic myeloid leukaemia, essential thrombocytosis, and polycythemia vera. Melanonychia is known as one of the side effects of hydroxyurea. In addition, this drug is capable of inducing non-melanoma Hutchinson's sign.A 71-year-old Japanese woman presented with melanonychia of the right great toe. She had no remarkable family history. For the past 14 years, she had been receiving 1,000 mg/day [...]