John Libbey Eurotext

European Journal of Dermatology


Spontaneous remission of methotrexate-associated lymphoproliferative disorder with Epstein-Barr virus type II latency Volume 28, issue 5, September-October 2018


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Department of Dermatology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki 036-8562, Japan

Methotrexate (MTX), an antimetabolite of folic acid, is an immunosuppressive agent that has been used as an anchor drug for the treatment of rheumatoid arthritis (RA). One of the many severe adverse effects of MTX is lymphoproliferative disorder (LPD). Here, we describe a case of MTX-associated LPD (MTX-LPD) that manifested as skin ulcers mimicking venous leg ulcers.An 80-year-old woman presented with a one-month history of erosive erythema and oedema on her lower leg. From the age of 50 to 73 years, [...]