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European Journal of Dermatology

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Serum levels of mannose-binding lectin in systemic sclerosis: a possible contribution to the initiation of skin sclerosis in the diffuse cutaneous subtype Volume 24, issue 1, January-February 2014

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  • Figure 1
Authors
Department of Dermatology,
University of Tokyo Graduate School of Medicine,
7-3-1 Hongo, Bunkyo-ku,
Tokyo 113-8655, Japan

Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by immune abnormalities, vasculopathy and fibrosis of the skin and certain internal organs. Recent evidence suggests the potential contribution of a dysregulated innate immune system to its pathogenesis [1]. Mannose-binding lectin (MBL), a member of the collectin family produced mainly by liver hepatocytes and, to a smaller extent, by gastrointestinal and reproductive tracts, binds to various pathogens as a pattern-recognition [...]