JLE

European Journal of Dermatology

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Occurrence rates of HLA-DRB1, HLA-DQB1, and HLA-DPB1 alleles in patients suffering from vitiligo Volume 8, issue 1, January - February 1998

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Authors
Department of Immunology, Faculty of Medicine, Comenius University, Sasinkova 4, 81108 Bratislava, Slovakia.

By investigating a group of 39 unrelated adults suffering from vitiligo it was found that al lel es HLA-DRB1*0701, -DQB1*0201, and -DPB1*1601 differed in their frequencies in comparison to those observed in the healthy population. The allele HLA-DRB1*0701 was found in 26.5% of patients compared to 14.2% in the healthy group (p < 0,01, RR = 2.17). The allele HLA-DQB1*0201 was present in 33.8% of patients compared to 21.2% (p < 0,025, RR = 1.89). The allele HLA-DPB1*1601 was found in 6.41% of patients compared to 2.05% in the healthy group (p < 0.05, RR = 3.3). No other significant deviations in the frequencies of investigated alleles were observed.