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European Journal of Dermatology

Major aphthous stomatitis induced by nicorandil Volume 7, issue 2, March 1997

Aphthous stomatitis may be drug-induced. Here we report the first two cases of major aphthous stomatitis induced by nicorandil, a new potassium-channel activator. A dosage increase, a high-dose treatment or a history of minor aphthous stomatitis may be considered as important cofactors.

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