European Journal of Dermatology
MENUHLA and susceptibility to two distinct types of drug-induced cutaneous reactions Volume 7, issue 5, July - August 1997
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- Key words: acute generalized exanthematous pustulosis, cutaneous drug reaction, HLA, maculopapular rash.
- Page(s) : 329-32
- Published in: 2000
The purpose of this work was to investigate HLA predisposition in two types of cutaneous drug reactions, which involve type IV hypersensitivity: maculo-papular papular rash, a common clinical form, and acute generalized exanthematous pustulosis, a rare form. The frequency of the DRB1*1301 DQB1*0603 haplotype was increased in the maculopapular rash (17.5% versus 6.4% in the control, relative risk (RR) = 3.7), whereas the HLA-B51(5) phenotype was increased in acute generalized exanthematous pustulosis (46.7% versus 14.6%, RR = 5.1); but the differences were not significant after correction for the p value. The culprit drugs were stratified in three categories: pristinamycin, other antibiotics and non-antibiotics: no HLA association could be established with the culprit drugs. DRB1*01 allele frequency was decreased in both types of cutaneous drug reactions, suggesting that this allele could confer a protective effect to the both types. Although these results suggest a HLA predisposition to cutaneous drug reaction, they need to be validated on a larger sample of patients.