JLE

European Journal of Dermatology

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Editorial: What's new this month? Volume 26, issue 5, September-October 2016

Authors
1 Department of Dermatology and Venereology, Hôpital de Beaumont, Lausanne University Hospital Center, Av. de Beaumont 29, CH-1011 Lausanne, Switzerland
2 Dermatology Department, Box 46, Addenbrooke's Hospital, Hills road, Cambridge, CB2 0QQ, UK
3 Dermatology Department, Hôpital Edouard Herriot, Lyon, France
4 Dermatology Department, Hospital de Santo António dos Capuchos - Centro Hospitalar de Lisboa Central, Alameda Santo António dos Capuchos 1169-050, Lisbon, Portugal
5 Department of Dermatology, Venerology and Allergology, University Hospital Wuerzburg, Joseph-Schneider-Str. 2, 97080 Wuerzburg, Germany
6 Dermatology Department, General University Hospital “Gregorio Marañon”, C/ Doctor Esquerdo 46, 28007 Madrid, and Dermatology Department, Clinica Dermatologica Internacional and Clinica Ruber, Madrid, Spain

Due to the increasing incidence of basal cell carcinoma (BCC), clinicians are facing a rising number of advanced BCC requiring complex surgery with potential disfigurement, or rare but lethal metastatic BCC, emphasizing the need for alternative therapeutic strategies. At a molecular level, it was shown that virtually 100% of BCC harbour an activating mutation in the Hedgehog (Hh) pathway. In most BCC, Patched receptor inactivation allows Smoothened (Smo) activation that in turn activates Gli transcription [...]