John Libbey Eurotext

European Journal of Dermatology

Delayed adverse reaction to sodium ioxaglic acid-meglumine Volume 11, issue 2, March - April 2001

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Authors
Service de Médecine D, Médecine Interne, Immunologie Clinique et Allergologie, CHU de Nancy, Hôpital Central, 29, avenue de Lattre-de-Tassigny, 54035 Nancy Cedex, France.
  • Key words: contrast media, delayed adverse reaction, drug hypersensitivity, eosinophilia, hepatitic cytolysis, maculopapular rash.
  • Page(s) : 134-7
  • Published in: 2001

A patient had a maculopapular rash, fever, hepatic cytolysis, rhabdomyolysis, eosinophilia and raised total IgEs after coronarography with ioxaglic acid-meglumine (Hexabrix®). Intradermal test to ioxaglic acid-meglumine was positive 48 hrs later. Histological examination revealed perivascular lymphocytic infiltration, with predominantly CD45Ro+ and CD8+ T cells and apoptotic basal keratinocytes. This case documents a late hypersensitivity reaction to ioxaglic acid-meglumine.