Department of Dermatology and Venereology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Department of Dermatology and Venereology, the Second Affiliated Hospital of Nanchang University, Nanchang, China
- Key words: circRNA, miRNA, UVA, fibroblast, collagen
- DOI : 10.1684/ejd.2018.3397
- Page(s) : 613-20
- Published in: 2018
The genes COL1A1 and COL1A2 encode the pro-alpha 1 and pro-alpha 2 chains of type I collagen, respectively, which is one of the main components of skin dermis. We have previously demonstrated that a circular RNA (a class of recently identified non-coding RNAs that exhibit regulatory potency by sequestering miRNAs like a sponge), which we termed circCOL3A1-859267, is downregulated and regulates type I collagen expression in UVA-exposed human dermal fibroblasts (HDFs). However, the precise mechanisms of circCOL3A1-859267-mediated collagen expression in UVA-irradiated HDFs remain unclear.