John Libbey Eurotext

European Journal of Dermatology


A comparative study of the T cell receptor Vb repertoire in erythema nodosum associated with Crohn’s disease and ulcerative colitis Volume 7, issue 2, March 1997


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Department of Dermatology, Tsuchiura Kyodo General Hospital, 11-7 Manabe Shinmachi, Tsuchiura city, Ibaraki 300, Japan.
  • Key words: inflammatory bowel disease, Crohn’sdisease, ulcerative colitis, erythema nodosum, T cell receptor.
  • Page(s) : 93-4
  • Published in: 2000

Recent studies show the potential role of superantigens in inflammatory bowel disorders. Erythema nodosum is a typical cutaneous manifestation associated with inflammatory bowel disease, although the incidence is rare. We have seen two cases of erythema nodosum in association with Crohn’s disease and ulcerative colitis, and examined the T cell receptor (TCR) Vb repertoire on the infiltrating lymphocytes in the skin and peripheral blood. Our results showed that Vb 14, 15, 17 and 20 were commonly expressed in the lesional skin of erythema nodosum associated with both Crohn’s disease and ulcerative colitis. However, Vb 8 was detected only in the skin of Crohn’s disease patients. Differences in the usage of the TCR Vb subsets may be involved in the differences between these inflammatory bowel diseases.