John Libbey Eurotext

Bulletin du Cancer


Identification and management of hereditary breast\ovarian cancers (2004 update) Volume 91, issue 3, Mars 2004

Médecin Interniste Département d‘Oncogénétique, Institut Paoli‐Calmettes, 232, bd Sainte Marguerite, 13009 Marseille Inserm E9939, 232, bd Sainte‐Marguerite, 13009 Marseille Génétique moléculaire, Service de génétique, Institut Gustave‐Roussy, 3, rue Camille‐Desmoulins, 94805 Villejuif Cedex UPR 2169 CNRS, 3, rue Camille‐Desmoulins, 94805 Villejuif Cedex Chirurgien chirurgie gynécologique, Institut Gustave‐Roussy, 3, rue Camille‐Desmoulins, 94805 Villejuif Cedex Oncologue médical, Groupe hospitalier Diaconesses, Croix St‐Simon, Site Reuilly, 18, rue du Sergent‐Bauchat, 75012 Paris Chirurgien, Département de gynécologie obstétrique, CHU Bretonneau, 37034 Tours Cedex Chirurgien, Service de chirurgie gynécologique et mammaire, Groupe hospitalier Pitié‐Salpêtrière, 47‐83, boulevard de l‘Hôpital, 75013 Paris Gynécologue, Centre Alexis‐Vautrin, avenue de Bourgogne, 54511 Vandœuvre‐lès‐Nancy Cedex Santé publique, Département de statistiques, Centre René‐Huguenin, 35, rue Daily, 92210 Saint‐Cloud
  • Key words: BRCA1, BRCA2, breast cancer, guidelines, ovarian cancer, preventive care, recommendations
  • Page(s) : 219-37
  • Published in: 2004

Background. Since the last recommendations, up to 2,500 new references had been published on that topic. Methodology. On the behalf of the health Minister, the Ad Hoc Committee consisted of 13 experts carried out a first version revisited by five additional experts who critically analyzed the first version of the report. Main updating. Breast and ovarian cancer seem to be associated with fewer deleterious mutation of BRCA12 and BRCA2 than previously thought. The screening of ovarian cancer is still not an attractive option while in contrast MRI may be soon for these young women with dense breast, the recommended option for breast cancer screening. The effectiveness of prophylactic surgeries is now well established. French position is to favor such surgeries with regard to a quality of life in line with the expected benefit, and providing precise and standardized process described in the recommendation. Conclusions. Due to methodological flaws, the low power and a short follow‐up of the surveys, this statement cannot however aspire to a high stability. ▾