John Libbey Eurotext

Bulletin du Cancer


Fas, Fas ligand, immune tolerance and cancer: involvement in colon cancer Volume 85, issue 2, Février 1998


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  • Key words: Fas (CD95), Fas ligand, tumor escape, colonic neoplasms.
  • Page(s) : 129-33
  • Published in: 1998

Fas and Fas ligand (FasL) are implicated in programmed cell death or apoptosis. In the immunological field, they are particularly important in auto-immunity, graft rejection and anti-tumoral response. Fas ligand expression on thymocytes, activated T lymphocytes, and in sites of immune privilege, suggests the importance of Fas/FasL interactions in negative control of the immune response. The recent description of FasL expression by tumoral cells, represents a new mechanism of immune escape for different cancer, and has been well studied in colon adenocarcinoma.