John Libbey Eurotext

Bulletin du Cancer

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Genetic alterations associated with pathologic differenciation of Wilm’s tumors Volume 84, issue 3, Mars 1997

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Authors
Laboratoire d’oncologie virale et moléculaire, Institut Curie, 91405 Orsay Cedex, France.
  • Key words: nephrogenesis, cancer, Wilms’ tumor, retrovirus, nov gene.
  • Page(s) : 289-303
  • Published in: 1997

Although several cytogenetic alterations have been associated with development of Wilms’ tumor, a multigenic neoplasia, molecular mechanisms of its induction, development and maintenance remain to be elucided. In order to characterize these different steps we have developed a unique animal model of Wilms’ tumor constituted by the MAV-1(N) induced avian nephroblastoma. This animal model led to the discovery in our laboratory of a new gene nov (nephroblastoma overexpressed gene) which is overexpressed in all avian nephroblastoma. Expression of the human nov gene (novH), which is down-regulated by WT1, is also deregulated in Wilms’ tumors. Nov characteristics suggest that it would play a role in the control of cellular proliferation and differenciation. Our observations also indicate that nov could be involved in the development of Wilms’ tumors, and represent a marker of their differentiation state.