CHU de Grenoble, Unité Inserm/UJF U823 IAPC, Clinique universitaire d'hépatogastroentérologie, Institut Albert-Bonniot, BP 217, 38043 Grenoble cedex 09, France
Nucléos(t)ide analogues used in the treatment of chronic hepatitis B, are usually well tolerated at short and long term. However, several observations have been reported of neuropathy, myopathy, and Fanconi syndrome especially under telbivudine. The main problem is the risk of renal failure requiring the follow-up of creatinine clairance under treatment. During pregnancy telbivudine and tenofovir can be used because of absence of teratogenicity in animals. However, there are no prospective study in human.