John Libbey Eurotext



Roseolovirus infections after stem cell transplantation Volume 6, issue 3, Mai - Juin 2002


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Laboratoire de virologie, Cervi, UPRES EA 2387, Groupe hospitalier Pitié-Salpêtrière, 83, boulevard de l'Hôpital, 75013 Paris

The immunosuppressive treatment following stem cell (SC) transplantation favours reactivation and replication of the Roseoloviruses. The high prevalence of human herpesviruses 6 and 7 (HHV6 and HHV7) among the general population and the lack of diagnostic methods to identify clearly active infections complicate the understanding of the real pathogenicity of these viruses. Nevertheless, HHV6 infections are frequent in SC graft recipients, and are associated to pathologies including encephalitis, pneumonitis, fever, skin rash, delayed engrafment and marrow suppression. The incidence of HHV7 infections and their potential clinical manifestations are less characterised. Further studies are required to establish the real impact of these viruses in SC transplanted patients. With that aim, methods for the rapid detection and the quantification of HHV6 and HHV7 are essential.