Hôpital Louis-Mourier, Service de Pédiatrie-Urgences, F-92700 Colombes, France
INSERM, Université Paris Diderot, Sorbonne Paris Cité, IAME, UMR 1137, F-75018 Paris, France
Hôpital Robert-Debré, Service de microbiologie, Centre National de Référence associé Escherichia coli
, F-75019 Paris, France
- Key words: Kingella kingae, arthritis, ostéomyélitis, molecular diagnosis, antibiotics
- DOI : 10.1684/mtp.2018.0667
- Page(s) : 5-11
- Published in: 2018
Kingella kingae is a Gram negative cocco-bacillus, identified in the 1960s, and is a normal inhabitant of the oropharynx of young children. Since 1990s, K. kingae has become the leading pathogen of osteoarticular infection (OAI) in children younger than 4 years of age in different countries. The diagnosis remains underestimated, because it is mainly based on home-made polymerase chain reaction (PCR).
Septic arthritis are the main clinical syndrome of K. kingae OAI, representing three quarters of all cases. Clinical and biological features are usually mild-to-moderate with a benign course. Oropharynx of young children is the reservoir and the portal of entry for K. kingae, then K. kingae clones are transmissible and several clusters of K. kingae OAI in day-care centers have been described worldwide.
K. kingae is almost always susceptible to beta-lactams, especially amoxicillin. Total duration of treatment was recently shortened to 4-7 days intravenously followed with 2-4 weeks orally.