Potential interplay between NFκB and PPARγ in human dermal microvascular endothelial cells cultured in low magnesium Volume 27, issue 2, April-May-June 2014
Dipartimento di Scienze Biomediche e Cliniche L. Sacco, Università di Milano, Milano, Italy
* Correspondence: AM Maier. Dipartimento di Scienze Biomediche e Cliniche Luigi Sacco, Università di Milano. Via GB Grassi, 74 Milano I-20157
- Key words: magnesium, microvascular endothelial cells, NFκB, PPARγ, chemokines
- DOI : 10.1684/mrh.2014.0365
- Page(s) : 86-93
- Published in: 2014
Dermal microvascular endothelial cells contribute to cutaneous inflammation by secreting proinflammatory cytokines and chemokines. We show here that low extracellular magnesium stimulates the secretion of interleukin 8 and monocyte chemoattractant protein-1 in dermal microvascular endothelial cells. This secretory pattern might result from interplay between NFκB, the master regulator of inflammation, and PPARγ, a transcription factor that has emerged as an inhibitor of inflammation. Indeed, both NFκB and PPARγ are activated in dermal microvascular endothelial cells cultured in low magnesium-containing medium. In conclusion, we hypothesize that PPARγ and NFκB might contribute to the response of these cells to low Mg.