John Libbey Eurotext

Magnesium Research


A 6-month follow-up of disability, quality of life, and depressive and anxiety symptoms in pediatric migraine with magnesium prophylaxis Volume 30, issue 4, October-November-December 2017


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1 Mother and Child Health Institute of Serbia, R. Dakica St. 6-8, 11070, Belgrade, Serbia
2 Clinic for Neurology and Psychiatry for Children and Youth Dr Subotica 6a, 11000 Belgrade, Serbia
3 University Children's Hospital, Tirsova 10, 11000 Belgrade, Serbia
4 Faculty of Medicine, University in Belgrade, Dr Subotica 2, 11000 Belgrade, Serbia
5 Institute of Pharmacology, Clinical Pharmacology and Toxicology, Dr Subotica 1/3, 11000 Belgrade, Serbia
* Correspondence: Jasna Jancic. Clinic for Neurology and Psychiatry for Children and Youth Dr Subotic 6a, 11000 Belgrade, Serbia
  • Key words: children, adolescents, treatment, prophylaxis, migraine
  • DOI : 10.1684/mrh.2018.0431
  • Page(s) : 133-41
  • Published in: 2017

Magnesium is frequently used for pediatric migraine prophylaxis. The aim of this study was to evaluate to which extent the disability levels, quality of life (QOL), and anxiety and depressive symptoms change after 6-month magnesium prophylaxis in pediatric migraine. This is a follow-up study of 34 children aged 7-17 years with migraine treated with oral magnesium. Disability due to migraine was assessed by the Pediatric Migraine Disability Assessment tool (PedMIDAS), QOL was assessed by the KIDSCREEN-27, and anxiety and depressive symptoms were assessed by the Revised Child Anxiety and Depression Scale (RCADS). PedMIDAS scores significantly decreased from baseline to end-point (F(df, dferror) = 11.10 (1.63, 50.49), p<0.001), as well as anxiety (F(df, dferror) = 8.95 (1.64, 50.67), p = 0.001) and depressive symptoms (F(df, dferror) = 8.91 (1.59, 49.29), p = 0.001). Considering the KIDSCREEN-27, scores for physical and psychological well-being and social support domain significantly increased from baseline to end-point (p≤0.01). After 6 months of magnesium prophylaxis, disability due to migraine significantly decreased, whereas physical and psychosocial well-being improved. Children also reported fewer anxiety and depressive symptoms. More follow-up and randomized controlled clinical trials are needed to propose clinical recommendations for magnesium prophylaxis in pediatric migraine.