L'Information Psychiatrique


Treatment targeting the intestinal microbiota and their applications in psychiatry. Volume 92, issue 10, Décembre 2016

1 Clinique Jeanne d’Arc-Hôpital Privé Parisien, 55 rue du cdt Mouchotte, Saint-Mandé, France CHU Carémeau, Nîmes, France Université Paris-Est, Inserm U955, Fondation FondaMental, Créteil, France
2 Unité de développement du tissu lymphoïde, Institut Pasteur, 25 rue du Dr Roux 75724 Paris, France
* Correspondance

While forecasts predict an increase in the prevalence of mental health disorders in the worldwide general population, the response rate to classical psychiatric treatment remains unsatisfactory. Resistance to psychotropic drugs can be due to clinical, pharmacological, pharmacokinetic, or pharmacodynamic factors. Among these factors, recent animal findings suggest that microbiota may have an underestimated influence on its host's behavior and on drug metabolism that may explain ineffectiveness or increased side effects of psychiatric medications such as weight gain. The objective of the present study was to synthesize data on microbiota-oriented treatments (probiotics, prebiotics, and diet intervention) and their potential therapeutic applications in psychiatry.