L'Information Psychiatrique


Facteurs de vunérabilité génétique des troubles bipolaires de l’humeur Volume 84, issue 2, février 2008

Service de psychiatrie, hôpital Albert-Chenevier et hôpital Henri-Mondor, Créteil, et Inserm U841, Equipe 15 (Psychiatrie génétique), faculté Henri-Mondor, Créteil, Pôle de psychiatrie, hôpital Henri-Mondor, 94010 Créteil Cedex

Factors of genetic vulnerability in bipolar mood disorders.A study of the factors of genetic vulnerability in bipolar mood disorders has met and is still meeting with numerous methodological difficulties such as a lack of knowledge on the genetic model of the illness, etiological and clinical heterogeneity, the absence of external validity criteria to define pathologies and the absence of biological or genetic validity of the diagnostic classifications of psychiatric pathologies. This overview illustrates the strategies set up in order to overcome these difficulties and puts the accent on identifying more valid phenotypical indicators, with the aim of facilitating analysis of the underlying genetic component. One analysis concentrates on the patients and aims to break down their heterogeneity in order to identify more homogeneous sub groups, more relevant to analysis of the genetic component (with the hope of reducing the underlying etiological heterogeneity). The other attempts to identify the phenotypical markers of genetic vulnerability in patients’ relatives who, though unaffected, can be at risk.