John Libbey Eurotext

European Cytokine Network

Increased serum IL-17A and Th2 cytokine levels in patients with severe uncontrolled asthma Volume 28, issue 1, March 2017

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Authors
1 Sysmex Corporation, Kobe, Japan
2 Division of System Biology of Disease, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan
3 Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Japan
* Correspondence: H Kurata, Sysmex Corporation, Hematology Product Engineering, 4-4-4 Takatsukadai, Nishi-Ku, Kobe 651-2271, Japan
  • Key words: asthma, endotype, uncontrolled asthma, serum cytokines, IL-17, Th2
  • DOI : 10.1684/ecn.2017.0390
  • Page(s) : 8-18
  • Published in: 2017

Asthma is a syndrome of chronic bronchial inflammation and airway remodelling. Initially, asthma has been categorized into atopic and nonatopic types, based on antigen-specific IgE levels. Moreover, recently, asthma has been classified into different endotypes based on its pathophysiology, leading to the selection of the most optimal and effective therapies. Although T helper cell type 2 (Th2) cytokines were proven to play critical roles in atopic asthma, IL-17A has been reported to be involved in severe refractory asthma.