John Libbey Eurotext

Bulletin du Cancer


PEA3 family of transcription factors and the regulation of oncogenesis Volume 93, issue 10, Octobre 2006


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UMR 8161, Institut de biologie de Lille, CNRS, Université de Lille I, Université de Lille II, Institut Pasteur de Lille, BP447, 1 rue Calmette, 59021 Lille Cedex, Laboratoire de virologie moléculaire, Faculté de Médecine, Université Libre de Bruxelles, CP 614, 808 route de Lennik, 1070 Brussels, Belgium, Laboratoire de biologie animale, Bâtiment 470, Faculté des Sciences d’Orsay, Université de Paris Sud, 91405 Orsay

Erm, Er81, and Pea3 are the three members of the PEA3 group which belong to the Ets transcription factors family. These proteins regulate transcription of multiple target genes, such as those encoding several matrix metalloproteinases (MMP), which are enzymes degrading the extracellular matrix during cancer metastasis. In fact, PEA3-group genes are often overexpressed in different types of human cancers that also over-express these MMP and display a disseminating phenotype. In experimental models, regulation of PEA3 group member expression has been shown to influence the metastatic process, thus suggesting that these factors play a key role in metastasis.