John Libbey Eurotext

Bulletin du Cancer

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Frequency of genetic disease and previous cancer in 493 adults with visceral or soft tissue sarcomas Volume 90, issue 10, Octobre 2003

Authors
Comité Sarcome du centre Oscar‐Lambret, Département de cancérologie générale, Laboratoire d‘anatomo‐pathologie, Département d‘imagerie médicale, Département de radiothérapie, Département de cancérologie urologique et digestive, Département de cancérologie gynécologique, Unité de pédiatrie, Centre Oscar‐Lambret, 3, rue Frédéric‐Combemale, 59020 Lille Cedex

Little is known about epidemiology of adults soft tissue and visceral sarcomas (ASTS). The frequency of previous cancers and associated genetic diseases has been analyzed out of 493 ASTS, treated between 1997 and 2002 at Oscar Lambret Cancer Center. Median age is 51, sex ratio is close to 1. Liposarcomas and malignant fibrous histiocytofibromas are the two main types (respectively 104 and 86 cases). Upper and lower limbs are the two main locations (respectively 176 and 75 cases). Fifteen patients had associated genetic disease, including 12 cases of Recklinghausen diseases. 7 out of those 15 patients have neurosarcoma. 30 patients have previous cancers, including 7 breast cancers, 3 lymphomas and 3 chronic lymphocytic leukemias. Four out of those 30 patients have two different previous cancers. 13 patients have radiation‐induced sarcomas, after an average 10‐year‐period, and an average dose of 53 Gy. Undifferenciated sarcomas are the main histologic type (8\13), followed by angiosarcomas (2\13). Radiation‐induced sarcomas are located in the chest wall (7\13), in pelvis (2\13) and head and neck (2\13). Those sarcomas are high grade (10 grade III tumours). ASTS epidemiology is complex with different risk factors depending on histologic type.