Epileptic Disorders


The localizing value of epileptic auras: pitfalls in semiology and involved networks Volume 21, numéro 6, December 2019


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1 IRCCS, Istituto delle Scienze Neurologiche di Bologna, UOC Neuropsichiatria Infantile, Bologna, Italy
2 University Emergency Hospital Bucharest; “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
3 Division of Neurology, Children's Mercy Hospital, University of Missouri Kansas City, Kansas City, USA
4 Department of Neurology and Comprehensive Epilepsy Program, Brain Institute, Nicklaus Children's Hospital, Miami, USA
5 Department of Neurology, University of Miami Miller School of Medicine, Miami, USA
* Correspondence: Angelo Russo Department of Pediatric Neurology, IRCCS - Institute of Neurological Sciences of Bologna, via Altura 3, Bologna, Italy

A more complete understanding of the epileptic aura represents an important challenge for localizing the epileptogenic zone and understanding brain networks. This review re-visits the localizing value of the epileptic aura, focusing on clinical pitfalls in epileptogenic zone detection and the importance of defining functional connectivity. We review the role of network node activation or alteration and its relationship to hub activation.