John Libbey Eurotext

Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from fœtal and adult brain tissue Volume 1, numéro 3, Septembre 1999

1. Kimelberg HK. Primary astrocyte cultures ­ a key to astrocyte function. Cell Mol Neurobiol 1983; 3: 1-16.

2. Kimelberg HK, Norenberg MD. Astrocytes. Sci Am 1989; 260: 44-55.

3. Schousboe A, Hertz L, Svenneby G. Uptake and metabolism of GABA in astrocytes cultured from dissociated mouse brain hemispheres. Neurochem Res 1977; 2: 217-29.

4. Larsson OM, Thorbek P, Krogsgaard-Larsen P, Schousboe A. Effect of homo-ß-proline and other heterocyclic GABA analogues on GABA uptake in neurons and astroglial cells and on GABA receptor binding. J Neurochem 1981; 37: 1509-16.

5. Schousboe A. Transport and metabolism of glutamate and GABA in neurons and glial cells. Int Rev Neurobiol 1981; 22: 1-45.

6. Schousboe A, Larsson OM, Wood JD, Krogsgaard-Larsen P. Transport and metabolism of gamma-aminobutyric acid in neurons and glia: implications for epilepsy. Epilepsia 1983; 24: 531-8.

7. Hansson E, Eriksson P, Nilsson M. Amino acid and monoamine transport in primary astroglial cultures from defined brain regions. Neurochem Res 1985; 10: 1335-41.

8. Löscher W. Valproate induced changes in GABA metabolism at the subcellular level. Biochem Pharmacol 1981; 30: 1364-6.

9. Löscher W. Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain. Neurochem Res 1993; 18: 485-502.

10. Sills GJ, Leach JP, Butler E, Carswell A, Thompson GG, Brodie MJ. Antiepileptic drug action in primary cultures of rat cortical astrocytes. Epilepsia 1996; 37 (Suppl. 4): 116.

11. Jacob JN, Hesse GW, Shashoua VE. Synthesis, brain uptake, and pharmacological properties of a glyceryl lipid containing GABA and a GABA-T inhibitor gamma-vinyl-GABA. J Med Chem 1990; 33: 733-6.

12. Leach JP, Sills GJ, Majid A, et al. Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes. Seizure 1996; 5: 229-34.

13. Suzdak PD, Jansen JA. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia 1995; 36: 612-26.

14. O'Connor ER, Sontheimer H, Spencer DD, de Lanerolle NC. Astrocytes from human hippocampal epileptogenic foci exhibit action potential-like responses. Epilepsia 1998; 39: 347-54.

15. Klee MR, Akaike N, Oomura Y, Manuyama T. Valproate reduces Na+-dependent GABA uptake. Pflugers Arch Eur J Physiol 1985; 405: R7.

16. Nilsson M, Hansson E, Ronnback L. Transport of valproate and its effects on GABA uptake in astroglial primary culture. Neurochem Res 1990; 15: 763-7.

17. Nilsson M, Hansson E, Ronnback L. Interactions between valproate, glutamate, aspartate, and GABA with respect to uptake in astroglial primary cultures. Neurochem Res 1992; 17: 327-32.

18. Löscher W. Effect of inhibitors of GABA transaminase on the synthesis, binding, uptake, and metabolism of GABA. J Neurochem 1980; 34: 1603-8.

19. Ross SM, Craig CR. Studies on gamma-aminobutyric acid transport in cobalt experimental epilepsy in the rat. J Neurochem 1981; 36: 1006-11.

20. Schousboe A, Larsson OM, Seiler N. Stereoselective uptake of the GABA-transaminase inhibitors gamma-vinyl GABA and gamma-acetylenic GABA into neurons and astrocytes. Neurochem Res 1986; 11: 1497-505.

21. Borden LA, Murali Dhar TG, Smith KE, Weinshank RL, Branchek TA, Gluchowski C. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 1994; 269: 219-24.

22. Dalby NO, Nielsen EB. Comparison of the preclinical anticonvulsant profiles of tiagabine, lamotrigine, gabapentin and vigabatrin. Epilepsy Res 1997; 28: 63-72.

23. Adkins JC, Noble S. Tiagabine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of epilepsy. Drugs 1998; 55: 437-60.

24. Borden LA, Smith KE, Gustafson EL, Branchek TA, Weinshank RL. Cloning and expression of a betaine/GABA transporter from human brain. J Neurochem 1995; 64: 977-84.

25. Johnson J, Chen TK, Rickman DW, Evans C, Brecha NC. Multiple gamma-aminobutyric acid plasma membrane transporters (GAT-1, GAT-2, GAT-3) in the rat retina. J Comp Neurol 1996; 375: 212-24.

26. Durkin MM, Smith KE, Borden LA, Weinshank RL, Branchek TA, Gustafson EL. Localisation of messenger RNAs encoding three GABA transporters in rat brain: an in situ hybridization study. Mol Brain Res 1995; 33: 7-21.