John Libbey Eurotext

Effects of valproate, vigabatrin and tiagabine on GABA uptake into human astrocytes cultured from fœtal and adult brain tissue Volume 1, numéro 3, Septembre 1999

Auteurs
Epilepsy Unit, Department of Medicine & Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland
  • Page(s) : 153-8
  • Année de parution : 2000

Astrocytes account for more than half of the glial cell population in the brain. One of their prime physiological roles is in the regulation of extracellular concentrations of a host of endogenous compounds including the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) [1, 2]. Astrocytes are involved in the active transport of GABA out of the synapse and in its mitochondrial metabolism. Given their important role in GABA homeostasis, [...]