John Libbey Eurotext

European Cytokine Network

MENU

Nicotine exerts neuroprotective effects by attenuating local inflammatory cytokine production following crush injury to rat sciatic nerves Volume 30, numéro 2, June 2019

Illustrations

  • Figure 1
  • Figure 2
  • Figure 3
  • Figure 4
  • Figure 5
  • Figure 6
Auteurs
1 The Fifth Hospital of Harbin, Department of Orthopedics, Harbin, China
2 Harbin Red Cross Central Hospital, Department of Gynecology and Obstetrics, Harbin, China
* Correspondence: Dewei Wang, The Fifth Hospital of Harbin, Department of Orthopedics, Harbin, China.
  • Mots-clés : nicotine, α7nAChR, inflammatory cytokine, peripheral nerve regeneration, crush injury
  • DOI : 10.1684/ecn.2019.0426
  • Page(s) : 59-66
  • Année de parution : 2019

Background

Recent studies have demonstrated that nicotine exhibited anti-inflammatory and neuroprotective properties by interacting with the alpha 7 nicotinic acetylcholine receptor (α7nAChR). However, the role of nicotine in regeneration during peripheral nerve injury has not been elucidated. The aim of this study was to investigate whether nicotine down-regulated production of proinflammatory cytokines and promoted peripheral nerve regeneration in rats.