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Nicotine exerts neuroprotective effects by attenuating local inflammatory cytokine production following crush injury to rat sciatic nerves Volume 30, issue 2, June 2019

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Authors
1 The Fifth Hospital of Harbin, Department of Orthopedics, Harbin, China
2 Harbin Red Cross Central Hospital, Department of Gynecology and Obstetrics, Harbin, China
* Correspondence: Dewei Wang, The Fifth Hospital of Harbin, Department of Orthopedics, Harbin, China.

Background

Recent studies have demonstrated that nicotine exhibited anti-inflammatory and neuroprotective properties by interacting with the alpha 7 nicotinic acetylcholine receptor (α7nAChR). However, the role of nicotine in regeneration during peripheral nerve injury has not been elucidated. The aim of this study was to investigate whether nicotine down-regulated production of proinflammatory cytokines and promoted peripheral nerve regeneration in rats.