European Cytokine Network
MENUNicotine exerts neuroprotective effects by attenuating local inflammatory cytokine production following crush injury to rat sciatic nerves Volume 30, numéro 2, June 2019
Auteurs
Background
1 The Fifth Hospital of Harbin, Department of Orthopedics, Harbin, China
2 Harbin Red Cross Central Hospital, Department of Gynecology and Obstetrics, Harbin, China
* Correspondence: Dewei Wang, The Fifth Hospital of Harbin, Department of Orthopedics, Harbin, China.
- Mots-clés : nicotine, α7nAChR, inflammatory cytokine, peripheral nerve regeneration, crush injury
- DOI : 10.1684/ecn.2019.0426
- Page(s) : 59-66
- Année de parution : 2019
Recent studies have demonstrated that nicotine exhibited anti-inflammatory and neuroprotective properties by interacting with the alpha 7 nicotinic acetylcholine receptor (α7nAChR). However, the role of nicotine in regeneration during peripheral nerve injury has not been elucidated. The aim of this study was to investigate whether nicotine down-regulated production of proinflammatory cytokines and promoted peripheral nerve regeneration in rats.