Magnesium Research


Magnesium chloride or magnesium sulfate: a genuine question Volume 18, numéro 3, September 2005

SDRM, 64 rue de Lonchamp, 92200 Neuilly, France, Laboratoire de physiologie et physiopathologie, Université P. et M. Curie, Paris, France, Laboratoire de toxicologie, Faculté de pharmacie, Université Louis Pasteur, Strasbourg, 67400 Illkirch-Grafenstaden, France, Laboratoire de pharmacologie, Faculté de pharmacie, Paris XI, Pierre Maurois, 92290 Chatenay-Malabry, France

MgSO 4 is routinely used in therapeutics despite its toxicity. The aim of the present review was to compare MgSO 4 and MgCl 2 effects in order to answer the question whether MgSO 4 could be or not replaced by MgCl 2. Considering that the two salts have both similar and proper effects, a clear-cut conclusion is not easy to draw. However, choosing MgCl 2 seems advisable because of its more interesting clinical and pharmacological effects and its lower tissue toxicity as compared to MgSO 4.