Epilepsy Center Bethel, Bielefeld, Germany, Department of Neurology, University of Pécs, Pécs, Hungary, National Institute of Psychiatry and Neurology, Budapest, Hungary, Department of Public Health Sciences, Karolinska Institute, Stockholm, Sweden, Institute of Behavioral Sciences, Semmelweis University, Budapest, Hungary
- Mots-clés : temporal lobe epilepsy, interictal discharges, seizure frequency, epilepsy duration, EEG
- Page(s) : 355-9
- Année de parution : 2005
Objectives. We wanted to investigate factors that are associated with frequency of interictal epileptiform discharges by investigating 303 patients with temporal lobe epilepsy (TLE). Methods. We included all patients who consecutively underwent the adult presurgical evaluation program at our center and who had intractable, medial TLE with complex partial seizures due to unilateral medial temporal lobe lesions. The interictal EEG samples were automatically recorded and stored on computer. The location and frequency of interictal epileptiform discharges were assessed by visual analysis of interictal EEG samples of 2-minute duration every hour. Results. There were 303 patients (aged 16-63) who met the inclusion criteria. The median interictal epileptiform discharge frequency was 15 IED/h, the median seizure frequency was 4 seizures/month. According to univariate analyses, we found that age at monitoring, epilepsy duration, and higher seizure frequency were associated with higher interictal epileptiform discharge frequency. In the logistic regression analysis, we found that higher seizure frequency (p < 0.001) and longer epilepsy duration (p = 0.007) were independently associated with higher spike frequency, while the age at monitoring was not. Conclusions. Seizure frequency and epilepsy duration (years of patient’s life with seizure activity) were independently associated with IED frequency, suggesting that IED are modulated by seizures.