John Libbey Eurotext

Rage and aggressive behaviour in frontal lobe epilepsy: description of a case and review of the mechanisms of aggressive behaviour in epilepsy and dementia Volume 23, numéro 2, April 2021

Vidéo

  • Rage and aggressive behaviour in frontal lobe epilepsy: description of a case and review of the mechanisms of aggressive behaviour in epilepsy and dementia

Illustrations

  • Figure 1
Auteurs
1 Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
2 Neurology Unit, Maggiore Hospital, Lodi, Italy
3 Divisionof Clinical Neurophysiology and Epilepsy Center, IRCCS Ospedale Policlinico San Martino, Genova, Italy
4 Neurology Clinic, University of Genova Medical School, Ospedale Policlinico IRCCS San Martino, Genova, Italy
5 Neurology Clinic, Department of Neurosciences and Rehabilitation, University of Ferrara, Italy
* Correspondence: Flavio Villani Divisionof Clinical Neurophysiology and Epilepsy Centre, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, Genova, Italy
a Authors equally contributed equally to this work.

The study of dementia and epilepsy may provide particular insight into behavioural alterations. We describe a rare case of ictal aggressive behaviour in a patient with focal epilepsy associated with a non-dominant dorso-lateral prefrontal lesion. During focal seizures, our patient showed intense agitation and anger, for a long time misinterpreted as psychogenic attacks, which disappeared after epilepsy surgery. The defined anatomical origin of such ictal emotional behaviour is not fully understood, however, the dorso-lateral prefrontal area appears to correlate less frequently with aggressiveness compared to the antero-mesial area. We describe the electroclinical data of our patient and provide a brief review of the mechanisms underlying aggressive conduct in epilepsy and dementia. An understanding of this mechanism could help to clarify the neural basis and treatment of violence associated with these and other neurological disorders. [Published with video sequence].