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Monoamine metabolism study in severe, early-onset epilepsy in childhood Volume 10, numéro 2, June 2008

Figure 1 Pathways for biosynthesis and catabolism of the biogenic monoamine neurotransmitters serotonin, dopamine, norepinephrine and the pterins.5HTP: 5 hydroxytryptophan; 5 HIAA: hydroxyindolacetic; HVA: homovanillic acid; 1 and 2-oxo TP: 1 and 2-oxo-hydroxytetrahydropterin; BH4: tetrahydrobiopterin; qBH2: quinonoid dihydrobiopterin; B H2: dihydrobiopterin; VMA: vanillylmandelic acid; 1: GTP cyclohydrolase 1; 2: 6-pyruvoyl-tetrahydrobiopterin synthase; 3: sepiapterin reductase; 4: carbonyl reductase; 5: aldose reductase; 6: dihydrofolate reductase; 7: dihydropteridine reductase; 8: tyrosine hydroxylase; 9: tryptophan hydroxylase; 10: aromatic L-aminoacid decarboxylase.