Division of Child Neurology, Children's Hospital of Richmond, Virginia Commonwealth University/Medical College of Virginia Hospitals, Richmond, Virginia, USA
Correspondence: John Pellock
Division of Child Neurology,
Children's Hospital of Richmond,
Virginia Commonwealth University/Medical College of Virginia Hospitals,
1001 East Marshall Street,
Richmond, Virginia, 23298-0211 USA
Prolonged seizures are associated with morbidity and mortality of varying degrees. It is important to recognize seizures early, and treat them appropriately. This leads to the best clinical outcome. There has been an emphasis on prompt treatment, but there exists a variety of poorly executed protocols. This review addresses the question of whether additional clinical trials are necessary, not only to answer for what purpose, but also, clearly, to examine the impact additional studies may have. Overall, the acute treatment of epilepsy emergencies in children has markedly improved with availability of out-of-hospital therapies, but additional studies to determine the most efficacious, maximally safe, and best tolerated treatments are needed.