John Libbey Eurotext

Epileptic Disorders

The Educational Journal of the

Interictal epileptiform discharges in sleep and the role of the thalamus in Encephalopathy related to Status Epilepticus during slow Sleep Volume 21, supplément 1, June 2019


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1 Centre for Epilepsy Surgery “C. Munari”, Centre of Sleep Medicine, Department of Neuroscience, Niguarda Hospital, Milan, Italy
2 Centre for Advanced Studies in Sleep Medicine, Dept. of Neurosciences, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Montréal, Canada
3 Child Neuropsychiatry, IRCCS, G. Gaslini Institute, Dept. of Neuroscience (DINOGMI), University of Genoa, Italy
4 National Institute of Clinical Neuroscience, Budapest, Hungary
* Correspondence: Péter Halász National Institute of Clinical Neuroscience, Lotz K.U.18, Budapest, 1026 Hungary
  • Mots-clés : continuous spike-and-wave discharges during sleep, EEG, encephalopathy related to status epilepticus during slow sleep, sleep, thalamocortical system
  • DOI : 10.1684/epd.2019.1058
  • Page(s) : 54-61
  • Année de parution : 2019

EEG activation of interictal epileptiform discharges (IEDs) during NREM sleep is a well-described phenomenon that occurs in the majority of epileptic syndromes. In drug-resistant focal epilepsy, IED activation seems to be related to slow wave activity (SWA), especially during arousal fluctuations, namely phase A of the cyclic alternating pattern (CAP). Conversely, in childhood focal epileptic syndromes, including Encephalopathy related to Status Epilepticus during slow Sleep (ESES), IED activation seems primarily modulated by sleep-inducing and maintaining mechanisms as reflected by the dynamics of spindle frequency activity (SFA) rather than SWA. In this article, we will review the effect of sleep on IEDs with a particular attention on the activation and modulation of IEDs in ESES. Finally, we will discuss the role of the thalamus and cortico-thalamic circuitry in this syndrome.