Epileptic Disorders
MENUGelastic seizures with dancing arising from the anterior prefrontal cortex Volume 16, numéro 2, June 2014
- Mots-clés : temporal lobe epilepsy, gelastic seizures, anterior prefrontal cortex, Brodmann area 10, neural networks
- DOI : 10.1684/epd.2014.0659
- Page(s) : 233-7
- Année de parution : 2014
Aim.This case report provides insight into the function of the anterior prefrontal cortex (aPFC), specifically Brodmann Area 10 (BA10), and its interconnectivity. Method. We present a 10-year-old patient with lesional epilepsy and ictal onset, localised to BA10 in the aPFC. Results. Thirty-four seizures were recorded. All seizures involved a demonstration of elation with laughter that was associated with a variety of different patterns of complex motor behaviour that included performing specific celebratory movements and acting out a Michael Jackson dance move. Electrographically, the seizures were all stereotyped and arose from the right frontal region, followed by a distinct left temporal ictal rhythm that corresponded with the onset of the behaviours. The lesion in the right aPFC was identified as a mixed lesion with both dysembryoplastic neuroepithelial tumour cells and type II cortical dysplasia. Conclusion.The electrographic analysis and unique seizure semiology suggest a connection between the aPFC and the contralateral temporal lobe. This neural pathway appears to be involved in the activation of previously formed procedural memories, creating an intensely positive emotional experience.