Disciplina de Neurociência, Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil
Krankenanstalt Rudolfstiftung, Messerli Institute, Veterinary University of Vienna, Vienna, Austria
Programa de Pós-Graduação em Distúrbios do Desenvolvimento, Laboratório de Neurobiologia e Metabolismo, Universidade Presbiteriana Mackenzie, São Paulo, SP, Brazil
Correspondence:Mariana Bocca Nejm
Department of Neurology and Neurosurgery,
Federal University of São Paulo Paulista Medical School,
Pedro de Toledo 669, 1st floor,
São Paulo, SP, 04039-032 Brazil
Objective. Patients with temporal lobe epilepsy (TLE) are at high risk of experiencing cognitive impairment. Such dysfunction is also observed in an animal model of TLE, the rat model of pilocarpine-induced epilepsy.
Methods. We investigated the effects of fish oil supplementation on spatial memory in rats with pilocarpine-induced epilepsy using the Morris Water Maze (MWM) test.
Results. Although rats with pilocarpine-induced epilepsy treated with fish oil learned the platform location significantly faster by Day 7 of the acquisition phase, spatial memory performance of these rats was unaffected by fish oil supplementation during probe trials.
Significance. Our study provides insights into the importance of considering nutraceutical strategiesfor enhancing cognitive abilities in patients with TLE.