John Libbey Eurotext

European Journal of Dermatology

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Immunocryosurgery for basal cell carcinoma: impact on circulating CD4+ CD25high T regulatory cells and serum cytokines Volume 30, numéro 5, September-October 2020

Illustrations

  • Figure 1
Auteurs
1 Department of Skin and Venereal Diseases, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece
2 Molecular Biology Unit, Laboratory of Haematology, University Hospital of Ioannina, Ioannina, Greece
3 Department of Pharmacology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece

Basal cell carcinoma (BCC) grows in a type-2 T-helper cell-dominated microenvironment, which is permissive for tumour growth [1]. Immunocryosurgery, the combination of daily imiquimod over five weeks and a relatively mild cryosurgery session at Day 14, is an efficacious, minimally invasive modality for the majority of BCC [2], and this timing of treatment is essential for the efficacy of this approach [3]. At the tissue level, the cryosurgery session reverses the initial imiquimod-induced accumulation [...]