John Libbey Eurotext

European Journal of Dermatology


Could anti-PD-1 be a therapeutic alternative for metastatic pleomorphic dermal sarcoma? Volume 29, numéro 6, November-December 2019


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1 Department of Dermatology, CIC 1413, CRCINA Inserm 1232, CHU Nantes, Nantes, France
2 Pathology Department, CHU of Bordeaux, Bordeaux, France

Soft-tissue sarcomas are a group of rare and histogenetically heterogeneous tumours. Currently, the recommended management for cutaneous sarcomas at the metastatic stage is palliative multidrug chemotherapy, but this demonstrates <10% efficacy with a mean response over 2-3 months [1]. The prognosis is therefore appalling. Immunotherapy has revolutionized the management of melanoma, leading to an extension of the use of anti-PD-1 drugs. We report the first case of a cutaneous soft tissue sarcoma [...]