40th year anniversary of HIV discovery: Evolving paradigms for cure strategies Volume 26, numéro 1, Janvier-Février 2022

1 Virus-Cell Interactions Laboratory, Lady Davis Institute for Medical Research 3999 Côte Sainte Catherine, Montréal, QC, H3T1E2, Québec, Canada
2 Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada
3 Department of Medicine, Division of Experimental Medicine, McGill University, Montréal, Québec, Canada
* Correspondance : A. Gatignol

2021 was the 40th anniversary of the discovery of an acquired immunodeficiency syndrome (AIDS) that was a fatal sentence at that time [1]. Two years later, the cause of AIDS was identified as a new retrovirus, later named Human Immunodeficiency Virus type 1 (HIV) [2]. The first treatments emerged in 1988 with reverse transcriptase inhibitors, but these only induced a temporary remission and soon gave rise to resistant viruses. In 1996, the anti-proteases became available; compounds that were specifically [...]