L’épigénétique du lymphome Volume 30, numéro 2, Mars-Avril 2024

Immunology and Pharmacology department, Weill Cornell Medicine, New York City, USA.
* Tirés à part : A. Melnick <amm2014@med.cornell.edu>
Links of interest : yhe author declares that he has no links of interest with this article.

Somatic mutations of transcription factors and chromatin modifiers are a genetic hallmark of B-cell lymphomas, the most common hematologic malignancy. Most B-cell lymphomas arise from B cells transiting the germinal center (GC) reaction during the humoral immune response. During this process B cells undergo a series of rapid phenotypic changes, induced through the immune synapse they form with specialized T follicular helper (TFH cells). During their proliferative burst, germinal center B-cells [...]