L’hématopoïèse clonale et les origines des cancers du sang Volume 29, numéro 1, Janvier-Février 2023

Dana-Farber Cancer Institute, Boston, États-Unis
* Tirés à part : B. Ebert
Liens d’intérêt : The authors declare that they have no links of interest regarding this article.

Aging is associated with a steady increase in the number of somatic mutations in nearly all tissues. In combination, the processes affected by these aberrant variants create a broad array of outcomes. Clonal hematopoiesis is characterized by the overrepresentation of blood cells expanded from a single clone, often due to a fitness advantage of a particular variant. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-associated condition in individuals who do not have a hematologic [...]