John Libbey Eurotext

European Journal of Dermatology


Sarcoidosis developing upon immune checkpoint inhibition in advanced uveal melanoma Volume 30, numéro 5, September-October 2020


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1 Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany
2 Institute for Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany

Sarcoidosis is a chronic inflammatory disease presenting with non-caseating granulomas, which may involve multiple organs, especially the lungs, lymph nodes and the skin. Sarcoidosis is a T-cell-mediated and Th17 lymphocyte-driven disorder presumably triggered by microbial or environmental agents [1]. Moreover, medication such as interferons, antiretroviral agents, and, more recently, PD1 immune checkpoint inhibitors, have been observed to trigger sarcoid-like lesions [2].We report on a 60-year-old [...]