European Journal of Dermatology


Perifollicular xanthoma occurring after treatment with osimertinib Volume 33, numéro 5, September-October 2023


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1 Hikone Municipal Hospital, Hikone, Hassaka Shiga 522-8539, Japan
2 Department of Dermatology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga 520-2192, Japan

Acneiform eruptions are common adverse effects of epidermal growth factor receptor (EGFR) inhibitors and are rarely accompanied by yellow papules, reported as perifollicular xanthomas, histologically showing perifollicular xanthomatosis [1, 2]. We present the first case of perifollicular xanthomas associated with osimertinib.An 86-year-old Japanese man was referred to our department due to the emergence of yellow macules on both cheeks, nine months after switching drugs, from gefitinib to osimertinib [...]