John Libbey Eurotext

European Journal of Dermatology


Overview of germline and somatic genetic alterations in basal and squamous cell carcinoma: a review of the current literature Volume 31, numéro 4, July-August 2021


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1 Dermatology Unit, Tor Vergata University of Rome, Policlinic of Tor Vergata of Rome, Rome, Italy
2 Anatomic Pathology Unit, Department of Biomedicine and Prevention, Tor Vergata University of Rome, Rome, Italy
3 Department of Medicine and Medical Specialties, Alcalá University, Madrid, Spain;
4 Dermatology Service, Pius Hospital of Valls, Spain
* Reprints

Non-melanoma skin cancers (NMSCs), including basal and squamous cell carcinomas, represent the most common malignancies among Caucasians. Over two million cases of NMSC occur each year in the US, with a progressive increase in incidence. There are well-known environmental risk factors, such as iatrogenic or ionizing radiation exposure, but the effect of chronic ultraviolet radiation, especially ultraviolet B radiation, is one of the main predisposing factors. Currently, based on our knowledge of the pathophysiology of most NMSCs, we have a better understanding of the associated genetic risk factors. The aim of this study was to evaluate the factors that contribute to the onset of NMSC through a comprehensive literature research.