European Journal of Dermatology


Do juxtaposed compound nevus and neurofibroma with melanocytic differentiation share an identical cell of origin in NF1? Volume 25, numéro 6, November-December 2015


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1 Institute of Pathology,
HELIOS Klinikum Emil von Behring,
Walterhöferstr. 11, 14165 Berlin,
2 Institute of Neuropathology,
University Hospital Münster, Münster,
3 Department of Ear,
Nose and Throat and Plastic Surgery,
HELIOS Klinikum Aue,
Aue, Germany

We report a 46-year-old man fulfilling the diagnostic criteria of Neurofibromatosis type 1 (NF1) who was admitted for surgical resection of a large neurofibroma at the upper back. At ages 20 and 36 years, a neurofibroma was partially removed from the same region but the lesion grew again continuously and became pruritic and painful. The tumor measured 258 × 43 × 159 mm by MRI. Macroscopically, the overlying skin was raised, hairy and hyperpigmented (figure 1). The tumor showed a pale-grey cut surface [...]