John Libbey Eurotext

European Journal of Dermatology


DIHS/DRESS-like eruption possibly induced by amoxicillin during treatment with nivolumab Volume 29, numéro 2, March-April 2019


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1 Department of Dermatology,
2 Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Nivolumab, an antibody against programmed cell death 1 (PD-1), exerts therapeutic effects on various malignancies by activating CD8+ T cells [1, 2]. However, since CD8+ T cells play essential roles in various inflammatory skin diseases, such as drug eruptions, there are concerns about the effect of nivolumab on the progression of such diseases.Most drug eruptions rarely relapse after discontinuation of the causative drug, with the exception of drug-induced hypersensitivity syndrome (DIHS)/drug reaction [...]