John Libbey Eurotext

European Journal of Dermatology


D-dimer as a potential blood biomarker for disease activity and treatment response in chronic urticaria: a focused review Volume 28, numéro 6, November-December 2018


1 Bispebjerg Hospital,
Department of Dermatology,
2 University of Copenhagen,
Center for Medical Research Methodology,
Department of Biomedical Sciences,
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  • Mots-clés : chronic urticaria, d-dimer, biomarker, disease activity, treatment response
  • DOI : 10.1684/ejd.2018.3443
  • Page(s) : 731-5
  • Année de parution : 2018

Chronic urticaria is an itchy skin disease, which is treated with antihistamines; however, a large group of patients are unresponsive to antihistamines alone and are thus treated with omalizumab, although a small fraction of these patients have particularly recalcitrant disease. Currently, there are no reliable biomarkers available to assess disease activity/severity and treatment response in chronic urticaria patients. However, it has been reported that high levels of d-dimer are observed during disease activity and are significantly reduced during periods of remission. We present a focused overview of studies investigating plasma d-dimer level as a biomarker for disease activity and treatment response in patients with chronic urticaria.