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European Journal of Dermatology

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Chronic perianal ulceration as the initial symptom of Langerhans cell histiocytosis in adults Volume 23, numéro 4, July-August 2013

Illustrations


  • Figure 1
Auteurs
1 Department of Dermatology, Venereology and Allergy,
University Hospital of WÜrzburg,
Josef-Schneider-Str. 2
97080 WÜrzburg, Germany
2 Department of Dermatology and Venereology,
Vivantes Clinic NeukÖlln,
Berlin, Germany
3 Department of Dermatology,
Medical University of Graz,
Graz, Austria

Langerhans cell histiocytosis (LCH) mainly affects children and rarely occurs in adults [1]. Mostly, LCH presents as single system disease (SS) affecting only one organ system; in multisystem disease (MS), bone, skin, mucosae, lung, liver, spleen, bone marrow, lymph nodes, hypothalamus and the pituitary gland can be involved [1-3]. We report two patients with perianal skin ulcerations as the initial symptom of LCH. Both were successfully treated with intravenous vinblastine and oral prednisone, according [...]