John Libbey Eurotext

European Journal of Dermatology


Angelica sinensis isolate SBD.4: composition, gene expression profiling, mechanism of action and effect on wounds, in rats and humans Volume 22, numéro 1, January-February 2012

Sunny BioDiscovery, 972 E. Main Str. Santa Paula CA, USA, State Key Laboratory of Quality Research on Chinese Medicine, Institute of Chinese Medical Sciences, Taipa Macao, China, Heart Diabetes & Weight Loss Center, New York, USA, Complex Carbohydrate Research Center, University of Georgia, Athens, USA, Euromed, Inc. Orangeburg, New York

This report characterizes an aqueous isolate (SBD.4) of one of the most broadly used Chinese medicinal herbs, Angelica sinensis, from the perspective of its application in skin and wound care. SBD.4 has been chemically defined and was found to increase the strength of healed wounds in retired breeder (older) rats. Furthermore, the mechanism of action of this Angelica sinensis isolate was tested in the zebrafish angiogenesis model, and in human skin substitutes by DNA microarray, revealing a bioactivity profile consistent with skin repair and regeneration. When combined with several types of wound dressings, SBD.4 increased type I collagen production in human dermal fibroblasts, and when formulated in nanosilver hydrocolloid dressing, it was found effective in chronic ulcer management in humans, demonstrating that botanical high-tech wound dressings can be successfully developed to improve the treatment of chronic lesions in humans.